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王有为教授
来源:武汉大学药学院    时间:2011-11-17    编辑:admin    点击:82119

姓名:王有为(WANG YOUWEI

性别:男

职务/职称:武汉大学药学院中药与天然药物研究所所长/二级教授(博士生导师)

通讯地址(含邮编):武汉市武昌东湖路185号武汉大学药学院(430071

Emailwhutcm@sina.com

电话:027-68759323(实验室);027-68759010(办公室)

传真027-68759850

学术经历概览:

1982年毕业于华中农业大学。1982年至1987年在中国农业科学院原子能利用研究所任研究实习员;1987年至2005年供职于中国科学院武汉植物研究所,2001年至2005年任副所长、首席研究员和博士生导师;2006年至今任武汉大学药学院教授,2007年至2016年任副院长,2008年至今任中药与天然药物研究所所长。

2001年至2017年,分别到新西兰皇家科学院(2001)、马来西亚国家医学研究所(2002)、法国国家健康与医学研究院(2003)、巴基斯坦卡拉奇大学H.E.J化学研究所(2005)、日本富山大学(2008)、英国剑桥大学(2009)、美国奥本大学(2009)、俄罗斯喀山大学(2010)和智利康塞普西翁大学(2017)作访问学者或合作交流。

荣誉头衔与学术兼职

国务院特殊津贴专家和湖北省有突出贡献中青年专家;国家教育部高等学校中药学类专业教学指导委员会委员国家中药产业技术创新战略联盟副理事长;中国植物学会药用植物与植物药专委会副主任委员;中华中医药学会中药毒理学与安全性研究分会常务理事;中国中西医结合学会中药专委会常务委员;中国中西医结合学会临床药理与毒理专委会常务委员;世界中医药学会联合会中药饮片质量标准专委会常务委员;世界中医药学会联合会道地药材多维评价专委会常务理事;世界中医药学会联合会森林康养研究专委会常务理事;湖北省暨武汉市植物学会常务理事湖北省暨武汉市微生物学会常务理事湖北省药学会理事湖北省中医药学会理事《植物科学学报》副主编,《中草药》、《天然产物研究与开发》等学术期刊编委

研究领域:

中药与天然药物学

研究兴趣与方向:

中药资源可持续利用系统的建立;中药材的地道性、质量稳定性与临床有效性之间的关系;中药和民族药的新资源与新用途;中药和民族药可食用资源的功能评价与开发利用;中药有效物质作用机理及相互关系

业绩概要:

多年来致力于中药资源可持续利用系统的建立,中药材的地道性、质量稳定性与临床有效性之间的关系,中药、民族药的新资源与新用途,中药和民族药可食用资源的功能评价与开发利用,中药有效物质作用机理及相互关系等研究方向,主持完成了国家重大专项、国家科技支撑计划、国家公益性行业专项、国家863计划等共30多个科研项目。在湖北省地道药材规范化种植及其示范基地建设,厚朴、茯苓、黄连与荷叶等湖北地道药材质量标准体系建设和系列产品开发,绿绒蒿、印度獐牙菜、花锚等藏药植物传统功效评价和莳萝子、菊苣子、新塔花等维药植物综合开发利用方面均作出了贡献。获省部级科技奖8项和国家二类新兽药证书3件,在中国、美国和英国分别获专利授权24项,发表学术论文200余篇,其中SCI论文近60篇,出版专著和教材共7

荣誉与奖励:

2018年,湖北省科技进步二等奖

2017年,中国中西医结合学会科学技术一等奖

2016年,湖北省科技进步二等奖

2009年,国家科技部中药现代化科技产业基地建设先进个人奖

2009年,武汉大学优秀教师

2007年,湖北省科技进步一等奖

2007年,武汉大学医学突出贡献奖

2006年,武汉大学先进科技工作者

2004年,湖北省有突出贡献的中青年专家

2004年,武汉市科技进步一等奖

2003年,湖北省科技进步二等奖

2003年,中国科学院与省市企业合作先进个人二等奖

2001年,国务院政府特殊津贴专家

培养优秀研究生:

马冰馨(博士生):获第七届朱裕壁医学奖(2017

  俊(博士生):获第五届朱裕璧医学奖(2012)、第五届向近敏教育基金奖(2012);

两次获得武汉大学研究生学术创新一等奖(20122013

  博(博士生):获第四届朱裕璧医学奖(2011)和武汉大学研究生学术创新一等奖(2012

  越(硕士生):获得武汉大学研究生学术创新二等奖(2012

  玲(硕士生):获得武汉大学研究生学术创新二等奖(2013

10年代表性学术论文(通讯作者):

1. Bingxin Ma, Xiaoshan Meng, Jing Tong, Lanlan Ge, Gao Zhou, Youwei Wang*. Protective effects of Coptis chinensis inflorescence extract and linarin against carbon tetrachloride-induced damage in HepG2 cells through the MAPK/Keap1-Nrf2 pathway. Food & Function  2018, 9: 2353-2361

2. Lanlan Ge, Ling Chen, Qigui Mo, Gao Zhou, Xiaoshan Meng, Youwei Wang*. Total phenylethanoid glycosides and magnoloside Ia from Magnolia officinalis var. biloba fruits inhibit ultraviolet B-induced phototoxicity and inflammation through MAPK/NF-κB signaling pathways.  Rsc Advances  2018, 8(8): 4362-4371

3. Jing Tong, Qigui Mo, Bingxin Ma, Lanlan Ge, Gao Zhou and Youwei Wang*. The protective effects of Cichorium glandulosum seed and cynarin against cyclophosphamide and its metabolite acrolein-induced hepatotoxicity in vivo and in vitro.  Food & Function  2017, 8: 209-219

4. Lanlan Ge, Wenhui Zhang, Gao Zhou, Bingxin Ma, Qigui Mo, Yuxin Chen, Youwei Wang*. Nine phenylethanoid glycosides from Magnolia officinalis var. biloba fruits and their protective effects against free radical-induced oxidative damage.  Scientific Reports  2017, 7: 45342. pp1-12

5. Bingxin Ma, Jing Wang, Jing Tong, Gao Zhou, Yuxin Chen, Jingsheng He, Youwei Wang*. Protective effects of Chaenomeles thibetica extract against carbon tetrachloride-induced damage via the MAPK/Nrf2 pathway.  Food & Function  2016, 7(3):1492-1500

6. Bingxin Ma, Jing Tong, Gao Zhou, Qigui Mo, Jingsheng He, Youwei Wang*. Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice.   Journal of Functional Food   2016, 21:455-462

7. Jing Tong, Bingxin Ma, Lanlan Ge, Qigui Mo, Gao Zhou, Jingsheng He, Youwei Wang*. Dicaffeoylquinic acid-enriched fraction of Cichorium glandulosum seeds attenuates experimental type 1 diabetes via multi-pathway protection. Journal of Agricultural Food Chemistry  2015, 63(50): 10791-10802

8. Yuxin Chen, Jing Tong, Lanlan Ge, Bingxin Ma, Youwei Wang*. Ethyl acetate fraction of Terminalia bellirica fruit inhibits rat hepaticstellate cell proliferation and induces apoptosis.  Industrial Crops and Products   2015, 76: 364-373

9. Bingxin Ma, Xiaoquan Ban, Bo Huang, Jingsheng He, Jun Tian, Hong Zeng, Yuxin Chen, Youwei Wang*. Interference and Mechanism of Dill Seed Essential Oil and Contribution of Carvone and Limonene in Preventing Sclerotinia Rot of Rapeseed. PLoS ONE  2015, 10(7), e0131733:1-15

10. Jing Tong, Xincheng Yao, Hong Zeng, Gao Zhou, Yuxin Chen, Bingxin Ma, Youwei Wang*. Hepatoprotective activity of flavonoids from Cichorium glandulosum seeds in vitro and in vivo carbon tetrachloride-induced hepatotoxicity. Journal of Ethnopharmacology  2015, 174: 355-363

11. Jun Tian, Xiaobin Zeng, Aijun Lv, Aihua Zhu, Xue Peng, Youwei Wang*. Perillaldehyde, a Potential Preservative Agent in Foods: Assessment of Antifungal Activity against Microbial Spoilage of Cherry Tomatoes.    LWT - Food Science and Technology    2015, 60(1): 63-70

12. Jun Tian, Xiaobin Zeng, Zhaozhong Feng, Xiangmin Miao, Xue Peng, Youwei Wang*. Zanthoxylum molle Rehd. Essential Oil as a Potential Natural Preservative in Management of Aspergillus flavus.   Industrial Crops and Products  2014, 60: 151-159

13. Bo Huang, Yuxin Chen, Bingxin Ma, Gao Zhou, Jing Tong, Jingsheng He, Youwei Wang*. Protective effect of Cichorium glandulosum seeds from ultraviolet B-induced damage in rat liver mitochondria.  Food & Function  2014, 5: 869-875

14. Yuxin Chen, Hong Zeng, Jun Tian, Xiaoquan Ban, Bingxin Ma, Youwei Wang*. Dill (Anethum graveolens L.) seed essential oil induces Candida albicans apoptosis in a metacaspase-dependent manner.  Fungal Biology  2014, 118(4): 394-401

15. Ying Diao, Chaozhu Yang, Mi Yan, Xingfei Zheng, Surong Jin, Youwei Wang*, Zhongli Hu*. De Novo Transcriptome and Small RNA Analyses of Two Amorphophallus Species.  PLoS ONE  2014, 9(4), e95428. doi:10.1371/journal.pone.0095428

16. Jing Tong, Shilpa Buch, Honghong Yao, Chengxiang Wu, Hsin-I Tong, Youwei Wang*, Yuanan Lu*. Monocytes-Derived Macrophages Mediated Stable Expression of Human Brain-Derived Neurotrophic Factor, a Novel Therapeutic Strategy for NeuroAIDS.  PLoS ONE  2014, 9(2), e82030. doi:10.1371/journal.pone.0082030

17. Jun Tian,Yuxin Chen, Bingxin Ma, Jingsheng He, Jing Tong, Youwei Wang*. Drosera peltata Smith var. lunata (Buch.-Ham.) C. B. Clarke as a feasible source of plumbagin: phytochemical analysis and antifungal activity assay.  World Journal of Microbiology and Biotechnology  2014, 30:737-745

18. Jingsheng He, Jianwei Fan, shengbo Li, Bo Huang, Xiaoquan Ban, Youwei Wang*. Genetic variability of cultivated Chaenomeles speciosa (Sweet) Nakai based on AFLP analysis. Biochemical Systematics and Ecology   2014, 57: 445-450

19. Bingxin Ma, Ling Zhu, Xiaoyan Zang, Yuxin Chen, Dong Li, Youwei Wang*. Coptis chinensis inflorescence and its main alkaloids protect against ultraviolet-B-induced oxidative damage.  Journal of Functional Foods 2013, 5(4): 1665-1672

20. Yuxin Chen, Hong Zeng, Jun Tian, Xiaoquan Ban, Bingxin Ma, Youwei Wang*. Antifungal mechanism of essential oil from Anethum graveolens seeds against Candida albicans.  Journal of Medical Microbiology 2013, 62:1175-1183

21. Song Liu, Dong Li, Bo Huang, Yuxin Chen, Xiaocong Lu, Youwei Wang*. Inhibition of pancreatic lipase, α-glucosidase, α-amylase, and hypolipidemic effects of the total flavonoids from Nelumbo nucifera leaves. Journal of Ethnopharmacology  2013, 149: 263-269

22. Gao Zhou, Yuxin Chen, Song Liu, Xingcheng Yao, Youwei Wang*. In vitro and in vivo hepatoprotective and antioxidant activity of ethanolic extract from Meconopsis integrifolia (Maxim.) Franch.  Journal of Ethnopharmacology  2013, 148: 664-670

23. Xincheng Yao, Ling Zhu, Yuxin Chen, Jun Tian, Youwei Wang*. In vivo and in vitro antioxidant activity and α-glucosidase, α-amylase inhibitory effects of flavonoids from Cichorium glandulosum seeds.  Food Chemistry  2013, 139: 59-66

24. Bo Huang, Lin Zhu, Song Liu, Dong Li, Yuxin Chen, Bingxin Ma, Youwei Wang*. In vitro and in vivo evaluation of inhibition activity of lotus (Nelumbo nucifera Gaertn.) leaves against ultraviolet B-induced phototoxicity.  Journal of Photochemistry and Photobiology B: Biology  2013, 121: 1-5

25. Ling Zhu, Bo Huang, Xiaoquan Ban, Jingsheng He, Yuxin Chen, Li Han, Youwei Wang*. Coptis chinensis inflorescence extract protection against ultraviolet-B-induced phototoxicity, and HPLC–MS analysis of its chemical composition.  Food and Chemical Toxicology  2012, 50(7): 2584-2588   

26. Jun Tian, Xiaoquan Ban, Hong Zeng, Jingsheng He, Yuxin Chen, Youwei Wang*.  The mechanism of antifungal action of essential oil from dill (Anethum graveolens L.) on Aspergillus flavus.  PLoS ONE  2012, 7(1): e30147. doi:10.1371/journal.pone.0030147

27. Jingsheng He, Bo Huang, Xiaoquan Ban, Jun Tian, Ling Zhu, Youwei Wang*. In vitro and in vivo antioxidant activity of the ethanolic extract from Meconopsis quintuplinervia.  Journal of Ethnopharmacology  2012, 141(1): 104-110

28. Jun Tian, Bo Huang, Xiuli Luo, Hong Zeng, Xiaoquan Ban, Jingsheng He, Youwei Wang*.  The control of Aspergillus flavus with Cinnamomum jensenianum Hand.-Mazz essential oil and its potential use as a food preservative.  Food Chemistry  2012, 130: 520-527

29. Jun Tian, Xiaoquan Ban, Hong Zeng, Bo Huang, Jingsheng He, Youwei Wang*.  In vitro and in vivo activity of essential oil from dill (Anethum graveolens L.) against fungal spoilage of cherry tomatoes.  Food Control  2011, 22 : 1992-1999

30. Hong Zeng, Jun Tian, Yuechen Zheng, Xiaoquan Ban, Jingsi Zeng, Yehong Mao, Youwei Wang*. In vitro and in vivo activities of essential oil from the seed of  Anethum graveolens L. against Candida spp. Evidence-Based Complementary and Alternative Medicine  2011, Article ID 659704, 8 pages  doi:10.1155/2011/ 659704

31. Xiaoquan Ban, Bo Huang, Jingsheng He, Yuxin Chen, Hong Zeng, Li Han, Youwei Wang*.  In vitro and in vivo antioxidant properties of extracts from Coptis chinensis inflorescence.  Plant Foods for Human Nutrition  2011, 66: 175-180

32. Yue Chen, Bo Huang, Jingsheng He, Li Han, Yichao Zhan, Youwei Wang*. In vitro and in vivo antioxidant effects of the ethanolic extract of Swertia chirayita.  Journal of Ethnopharmacology  2011, 136: 309-315

33. Jun Tian, Xiaoquan Ban, Hong Zeng, Jingsheng He, Bo Huang, Youwei Wang*. Chemical composition and antifungal activity of essential oil from Cicuta virosa L. var.latisecta Celak.  International Journal of Food Microbiology  2011, 145(2-3) : 464-470

34. Bo Huang, Jingsheng He, Xiaoquan Ban, Hong Zeng, Xincheng Yao and Youwei Wang*. Antioxidant activity of bovine and porcine meat treated with extracts from edible lotus (Nelumbo nucifera) rhizome knot and leaf.  Meat Science  2011, 87(1): 46-53

35. Bo Huang, Haibin Ke, Jingsheng He, Xiaoquan Ban, Hong Zeng, Youwei Wang*. Extracts of Halenia elliptica exhibit antioxidant properties in vitro and in vivo. Food and Chemical Toxicology  2011, 49: 185–190

36. Bo Huang, Xiaoquan Ban, Jingsheng He, Hong Zeng, Peng Zhang, Youwei Wang*.  Hepatoprotective and antioxidant effects of the methanolic extract from Halenia elliptica.  Journal of Ethnopharmacology  2010, 131(2):276-281

37. Bo Huang, Xiaoquan Ban, Jingsheng He, Jing Tong, Jun Tian, Youwei Wang*. Comparative analysis of essential oil components and antioxidant activity of extracts of Nelumbo nucifera from various areas of China. Journal of Agricultural Food Chemistry  2010, 58:441-448

38. Bo Huang, Xiaoquan Ban, Jingsheng He, Jing Tong, Jun Tian, Youwei Wang*.  Hepatoprotective and antioxidant activity of ethanolic extracts of edible lotus (Nelumbo nucifera Gaertn.) leaves.  Food Chemistry  2010, 120: 873-878

39. Jingsheng He, Ling Chen, Ying Si, Bo Huang, Xiaoquan Ban, Youwei Wang*.  Population structure and genetic diversity distribution in wild and cultivated populations of the traditional Chinese medicinal plant Magnolia officinalis subsp.biloba (Magnoliaceae).  Genetica  2009, 135: 233-243

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