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刘鑫教授
来源:武汉大学药学院    时间:2011-7-11    编辑:admin    点击:36943

姓名:刘鑫                                    性别:女

职称:教授

电话:027-69759869                             E—maillx@whu.edu.cn

通讯地址:武汉大学东湖路1855号楼7

工作地址:武汉大学东湖路1851号楼副5

u  教育和工作经历:

1994—1998, 武汉大学,生命科学学院生物学基地班,本科生

2000—2005, 武汉大学,生命科学学院病毒专业,硕士博士连读

2005—2008, 美国哈佛大学医学院,博士后

2009—2016, 武汉大学药学院,副教授

2016—现在, 武汉大学药学院,教授

u  获得荣誉:

2009 楚天学子

2012 武汉市“黄鹤英才”

u  教学工作:

细胞生物学(主讲),本科生课程

生物技术制药(主讲),本科生双学位课程

生理生化技术与现代药学研究(主讲),研究生课程

u  教学课题:

主持:武汉大学医学部本科教学项目,2014

主持:武汉大学研究生精品课程项目,2014-2016

u  研究领域:

肿瘤的血管生成调控机制

抗肿瘤药物及相关机制研究

抗病毒药物及相关机制研究

u  学术研究课题:

主持:武汉大学211人才项目,2010

参加:973计划项目(项目号2010CB529800),2010-2014

主持:国家自然科学基金面上项目(项目号30971456),负责人,2010-2012

主持:武汉大学医学部种子基金,2014

主持:国家自然科学青年基金项目(项目号31400155),负责人,2015-2017

主持:国家自然科学基金面上项目(项目号81472550),负责人,2015-2018

u  近期发表论文著作 (* 通讯作者)

1Xu J, Jiang Y, Wan L, Wang Q, Huang Z, Liu Y, Wu Y, Chen Z, Liu X*.Feeding recombinant E. coli with GST-mBmKTX fusion protein increases the fecundity and lifespan of Caenorhabditis elegans. Peptides. 2017 Mar;89:1-8.

2Chen L, Zhang J, Xu J, Wan L, Teng K, Xiang J, Zhang R, Huang Z, Liu Y, Li W, Liu X*. rBmαTX14 Increases the Life Span and Promotes the Locomotion of Caenorhabditis Elegans. PLoS One. 2016 Sep 9;11(9):e0161847.  

3Teng K, Deng C, Xu J, Men Q, Lei T, Di D, Liu T, Li W, Liu X*. Nuclear localization of TEF3-1 promotes cell cycle progression and angiogenesis in cancer. Oncotarget. 2016 Mar 22;7(12):13827-41.1TOPIF 5.998

4Chen J, Zhang J, Xiang Y, Xiang L, Liu Y, He X, Zhou X, Liu X*, Huang Z*. Extracts of Tsai Tai (Brassica chinensis): enhanced antioxidant activity and anti-aging effects both in vitro and in Caenorhabditis elegans. Food &Function. 2016 Feb 17;7(2):943-52.  1TOPIF 2.795

5Qiao C, Jiang Y, Deng C, Huang Z, Teng K, Chen L, Liu X*. Characterization of the transcriptional activation domains of human TEF3-1 (transcription enhancer factor 3 isoform 1). Arch Biochem Biophys. 2015 Mar 1;569:54-61.

6Liu T, Men Q, Wu G, Yu C, Huang Z, Liu X*, Li W*. Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells. Oncotarget.2015 Apr 10;6(10):7992-8006.1TOPIF 5.998

7Wang H, Liu T, Li L, Wang Q, Yu C, Liu X*, Li W*. Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species. Cell Biosci. 2015 Jan 14;5:4.

8Xiao W, Jiang Y, Men Q, Yuan L, Huang Z, Liu T, Li W, Liu X*. Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo. Int J Oncol.2015,46(1):360-8.

9Liu X#, Zhao D#, James L, Li J, Zeng H. Requirement of the nuclear localization of transcription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factor.  FASEB J.2011, 25:1188-97. #共同第一作者)(2TOPIF 5.480

10Liu X, Zhao D, Qin L, Li J, Zeng H.Transcription Enhancer Factor 3 (TEF3) Mediates the Expression of Down Syndrome Candidate Region 1 Isoform 1 (DSCR1-1L) in Endothelial Cells.   J Biol Chem. 2008, 283:34159-67.2TOPIF 4.477

11Liu X#, Zhou W#., Qi Y. Expression of SLAM (CDw150) on SF9 cell surface mediates Measles Viral infection in the nonpermissive cells through SLAM/MVH interaction.  Microbes Infect. 2005,7:1235-45.#共同第一作者)

12Huang Y#, Liu X#, Dong L, Liu Z, He X, Liu W. Development of viral vectors for gene therapy for chronic pain. Pain Res Treat. 2011, 968218. doi: 10.1155/2011/968218 #共同第一作者)

13Yang F, Ai W, Jiang F, Liu X, Huang Z, Ai S, Preclinical Evaluation of an Epidermal Growth Factor Receptor-Targeted Doxorubicin-Peptide Conjugate: Toxicity, Biodistribution, and Efficacy in Mice. Journal of Pharmaceutical Sciences. 2016;105(2):639-649.

14Mei L, Chen Y, Wang Z, Wang J, Wan J, Yu C, Liu X, Li W. Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21. Br J Pharmacol. 2015 May;172(9):2232-45.

15Li J, Chen Y, Wan J, Liu X, Yu C, Li W. ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells. Br J Pharmacol. 2014 Jul;171(13):3182-95. 

16Lei T, Li H, Fang Z, Lin J, Wang S, Xiao L, Yang F, Liu X, Zhang J, Huang Z, Liao W. Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress.Neural Regen Res. 2014 Feb 1;9(3):260-7.

17Yi C, Liu X, Liu Y, Lu S, Qi Y. Hemagglutinin protein of measles virus induces apoptosis of HeLa cells via bot extrinsic and intrinsic pathways.  Can J Microbiol. 2013 , 59:814-24.

18Ai S, Jia T, Ai W, Duan J, Liu Y, Chen J, Liu X, Yang F, Tian Y, Huang Z.  Targeted delivery of doxorubicin through conjugation with EGF receptor-binding peptide overcomes drug resistance in human colon cancer cells.  Br J Pharmacol.  2013 Apr;168(7):1719-35

19Ai S, Duan J, Liu X, Bock S, Tian Y, Huang Z. Biological evaluation of a novel Doxorubicin-peptide conjugate for targeted delivery to EGF receptor-overexpressing tumor cells. Mol Pharm. 2011, 8:375-86.

 

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