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胡先明教授
来源:武汉大学药学院    时间:2011-12-1    编辑:admin    点击:67373

姓名:胡先明 (Hu Xianming)
性别:男
职务/职称:教授,博士生导师,病毒学国家重点实验室学术带头人。湖北省中小企业共性技术药物及药用材料研发推广中心主任
通讯地址: 武汉大学药学院,湖北省武汉市武昌区东湖路185号   邮编:430071
电话:027-68759987(办公室);传真:027-68759850
电子信箱:xmhu@whu.edu.cn
(注:从2016年起不再招收研究生) 
 
学习经历:
1978.10-1981.11:武汉大学化学系理学硕士;
1992.10-1995.12:荷兰格罗宁根大学化学系博士学位。
 
主要研究兴趣:
(1)       合成药物化学及天然产物化学;
(2)       手性技术及手性药物研究;
(3)       生物医药材 料。


社会兼职:
中国药学会高级会员,药物化学专业委员会委员,湖北省药学会常务理事,副理事长,药物化学专业委员会主任委员。


Hu Xianming (Prof. Dr.) obtained a master degree of science from the Chemistry Department of Wuhan University and his Ph.D. degree from Groningen University of the Netherlands in 1995. Recent research interests at his laboratory focus on:
(1)       Medicinal chemistry including natural products and traditional medicine.
(2)       Biomaterials and drug delivery system.
 
phone number:0862768759987(O); fax:0862768759850
E-mail addr: xmhu@whu.edu.cn
 
近期研究课题
(1)     环丙烷类抗癫痫和抗惊厥药物及其抗病毒作用研究
(2)     大环内酯类抗生素的设计与合成
(3)     胺基甾体及甾类神经肌肉阻断剂的设计与合成
(4)     黄酮类抗病毒药物的设计与合成
(5)     茯苓活性多糖抗肿瘤冻干粉针剂的研制
(6)     基于茯苓多糖的新型药用辅料的开发
(7)     其它企业委托课题和外包服务
 
近期发表部分论文Recentpublications (Selected)
 
2009年
1. Qifeng Zhu, Yuanhu Pan, Zaixu Xu, Ruimin Li, Guofu Qiu, Wenjin Xu, Xianbing Ke, Lamei Wu, Xianming Hu*, Synthesis and potential anticonvulsant activity of new N-3-substituted 5, 5-cyclopropane spirohydantoins, European Journal of Medicinal Chemistry, 2009, 44, 296-302.
2. Xiao Ju Zhoua, Yi Mu Yib, Jing Wanb, Xian Ming Hua,* Preparation and body distribution of freeze-dried powder of ursolic acid phospholipid nanoparticles, Drug Development and Industrial Pharmacy, 2009 , 35(3), 305 – 310.
3. Xiao Ju Zhou, Yan Hu, Yanping Tian, Xian Ming Hu*, Effect of N-trimethyl chitosan enhancing the dissolution properties of the lipophilic drug cyclosporin A, Carbohydrate Polymers, 2009, 76(2),285-290.
4. Xianbing Ke, Hao Hu, Keda Zhang, Wenjin Xu, Qifeng Zhu, Lamei Wu, and Xianming Hu*, Significant Steroids: Effective and General Synthesis of 4α- and 4β-Amino-5α-Androstanes, Chemical Communications,2009,1037-1039.
5. Yan Hu, Xiaoju Zhou, Yong Lu, Chengyang Hu, Xianming Hu*, Novel Biodegradable Hydrogels based on Pachyman and its Derivatives for Drug Delivery, International Journal of Pharmaceutics, 2009, 371, 89–98.
6. Xianbing Ke, Hao Hu, Dingshan Zhou, Wenjin Xu, Qifeng Zhu, N. Pulla Reddy, Xianming Hu*, A Facile and General Synthesis of  2β-Aminosteroids, Synthesis, 2009, 8, 1255-1260.
7. Wenjin Xu, Jun Zhang, Hao Guo, Qifeng Zhu and Xianming Hu*, The Influence of Substituents on the Hydroxyl-Bearing Carbon in the Aza-Payne Rearrangement of Aziridinemethanols, Letters in Organic Chemistry, 2009, 6, 412-415.
8. Yuling Xiao, Qifeng Zhu, Wenjin Xu, Lamei Wu, Shucai Liang, Xianming Hu*. Preparation and characterization of a novel pachyman-based pharmaceutical aid II. A pH-sensitive, biodegradable and biocompatible hydrogel for controlled release of protein drugs, Carbohydrate Polymers, (2009) , 77(3), 612-620.
 9.Wenjin Xu, Hao Guo, Jun Zhang, Qifeng Zhu, Xianming Hu,*.Asymmetric reduction of acetophenone using a,a-disubstituted aziridinemethanols and borane. Journal of Molecular Catalysis A: Chemical,(2009), 300(1-2), 25-28.


 
2010年
1. Zhongyuan Wu, Yong Lu, Ming Luo, Xianran He, Yuling Xiao, Jin Yang, Yuanhu Pan, Guofu Qiu, Hao Guo, Hao Hu, Dingshan Zhou and Xianming Hu,Synthesis and antibacterial activity of 3-O-carbamoyl derivatives of 6,11-di-O-methylerythromycin A: A novel class of acylides, European Journal of Medicinal Chemistry,  2010, 45(9): 3636-3644.
2. Xianran He, Guanpeng Qiu, Jin Yang, Yuling Xiao, Zhongyuan Wu, Guofu Qiu, Xianming Hu. Synthesis and anticonvulsant activity of new 6-methyl-1-substituted-4, 6-diazaspiro[2.4]heptane-5, 7-diones. European Journal of Medicinal Chemistry, 2010, 45(9): 3818-3830.
3. Zhongyuan Wu, Yong Lu, Ming Luo, Xianran He, Yuling Xiao, Jin Yang, Yuanhu Pan, Guofu Qiu, Yinya Xu, Wenhong Huang, Ping Long, Ruimin Li and Xianming Hu. Synthesis and antibacterial activity of novel 4″-carbamates of 6,11-di-O-methylerythromycin A. The Journal of Antibiotics, 2010, 63(7):343-350.
4. Jin Yang, Yuling Xiao, Xianran He, Zhongyuan Wu, Guofu Qiu, Xianming, Hu, Aesculetin-induced apoptosis through ROS-mediated mitochondrial dysfunction pathway in human cervical cancer cells. J. Asian Nat. Prod. Res., 2010, 12(3): 185– 193.
5. Xianran He, Min Zhong, Tao Zhang, Wen Wu, Yuling Xiao, Jin Yang, Zhongyuan Wu, Yuanhu Pan, Guofu Qiu, Xianming Hu*. Synthesis and anticonvulsant activity of N-3-arylamide substituted 5,5-cyclopropanespirohydantoin derivatives. European Journal of Medicinal Chemistry, 45 (2010) 5870-5877
 
近年申报专利
 
(1)胡先明,柯贤炳,胡昊,2α,3α-环氧-16α-溴-5α-雄甾-17-酮的合成方法,申请号200710052447.3 申请日 07.06.11。ZL 2007 1 0052447.3
(2)胡先明,朱齐凤,5-环丙烷螺环乙内酰脲衍生物的制备方法及药物应用,申请号:200810047026.6
(3)胡先明 柯贤炳 胡昊,3α-羟基-2β-胺基-5α-雄甾-17-酮化合物的合成方法,申请日:2009.01.15;申请号:200910060520.0
(4)胡先明,肖玉玲,段小六,周小菊,刘华华,活性羧甲基茯苓多糖及其生产工艺和应用,申请号200910273267.7
(5)胡先明,吴仲元,鲁勇,罗明,4“-取代的6, 11-二-氧-甲基红霉素A的衍生物。申请号:201010188983.8
(6)胡先明,吴仲元,鲁勇,罗明,3-氧-取代的6, 11-二-氧-甲基红霉素A的衍生物。申请号:201010195098.2
(7)胡先明,贺贤然,N-3-芳酰胺-5-环丙烷螺环乙内酰脲衍生物及其制备方法和应用。申请号:201010196044.8
 

 

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