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王 巍

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王巍.png

姓名:王巍
性别:男
职务/职称:副教授,楚天学子

通讯地址:武汉大学药学院,湖北省武汉市武昌区东湖路185

办公地址:武汉大学东湖路185号武汉大学医学部1号楼8楼
邮编:430071
Email: waw6@whu.edu.cn 
电话:  

学习简历

2005 获武汉大学理学博士学位
2000 
获武汉大学化学系学士学位


工作简历

2011-至今   武汉大学药学院
2008-2011     
美国匹兹堡大学(University of Pittsburgh) 博士后
2006-2008    
美国南伊利诺斯大学 (Southern Illinois University Carbondale) 博士后
2005-2006    
上海无锡药明康德新药开发有限公司高级研究员


研究领域:

融合合成化学和计算机辅助药物设计技术开展针对抗病毒药物和肿瘤蛋白相互作用靶点的药物设计和发现工作,开展对功能蛋白结构域到活性小分子的“翻译”研究,主要针对蛋白蛋白相互作用进行相应功能小分子的药物设计与合成

1. 开展基于多组分反应的多肽、拟肽合成药物化学研究。

2. 新有机合成反应,新试剂与新技术(特别是不对称合成反应技术)在药物合成的应用。

3. 建设多组分反应的化合骨架数据库,开发新型多组分反应化学骨架,建立快速构建化合物库的合成能力。

4. 利用生命科学研究成果,特别是最新细胞内信号传导,通路以及相关结构生物学研究进展,开展生物活性分子化合物的设计。

5. 合作开展应用基于锚点骨架和基于结构的药物设计,寻找和发现新先导物,充分利用在蛋白蛋白相互作用调节剂中的经验,直接考虑化合物与靶点蛋白或核酸三维结构匹配和电子分布匹配进行相应设计,脱离传统盲目组合化学合成,利用多组分反应研究基础进行构效关系,进行先导物的结构优化和化学合成。

6. 利用独特多组分反应合成的化学骨架发散型的化合物库,利用国内外各种细胞筛选平台合作进行高通量筛选研究


研究技术手段:

有机合成技术(肽类似物,拟肽以及肽键替代),高分子合成技术,计算机辅助药物设计,虚拟化合物库设计,评估与构建,HIV-1衣壳蛋白组装模型,抗凋亡蛋白抑制评价



承担课题与经费:

主持

1 主持武汉大学引进人才科研启动经费,2012.1 – 2014.12

2  国家自然科学青年基金,2013.1-2015.12

3)    武汉大学医学部科研创新种子基金项目, 2014.1-2014.12

4)    湖北省自然科学基金面上项目,2015.1-2016.12

5)    农业部检定所农药安全评价,2015-2017

6)    武汉大学自主科研个人及交叉项目


参加多项校级,省部级课题。



教学情况:

研究生课程:新药研发与申报

本科生课程:计算机辅助药物设计

完成医学部本科生教学改革项目一项,主持研究生精品课程一项


科研成果:

1.    Feature-derived graph regularized matrix factorization for predicting drug side effects, Neurocomputing, Wen Zhang, Qianlong Qu, Yunqiu Zhang, Wei Wang, 2018, 287, 154-162

2.     The linear neighborhood propagation method for predicting long non-coding RNA –protein interactions, Neurocomputing, Wen Zhang, Qianlong Qu, Yunqiu Zhang, Wei Wang, 2018, 273, 526-534

3.          Recent Advances in Gossypol Derivatives and Analogues: A Chemistry and Biology View. Lu Y., Li J., Dong C., Huang J., Zhou H.-B.,* Wang W.* Future Med. Chem. 2017, V9, No11.1243-1275

4. Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins, Yuzhi Lu, Shuangchan Wu, Yuan Yue, Si He, Jun Li, Jun Tang, Wei Wang*, and Hai-Bing Zhou*, ACS Med. Chem. Lett., 2016, 7 (12), pp 1185–1190,

5.  Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors, Yu Li, Guiquan Xia, Qi Guo, Li Wu, Shizhen Chen, Zhigang Yang, Wei Wang, Zhong-Yin Zhang, Xin Zhouc, Zhong-Xing Jiang*, Med. Chem. Commun., 2016,7, 1672-1680,

6.    Isocyanides as Influenza A Virus Subtype H5N1 Wild-Type M2 Channel Inhibitors, Shuwen Wu, Jing Huang, Sabrina Gazzarrini, Si He, Lihua Chen, Dr. Jun Li, Li Xing, Chufang Li, Ling Chen, Constantinos G. Neochoritis, George P. Liao, Haibing Zhou, Alexander Dömling, Anna Moroni, Wei Wang*,CHEMMEDCHEM, 2015, 10(11), 1837-1845,

7.     HIV衣壳蛋白结构及其药物小分子进展李俊,王巍*,药学学报,2015, 50(9),1088-1095

Progress in the study of HIV capsid structure and drug discovery, Jun Li, Wei Wang, yao xue xue bao, 2015, 50(9), 1088-1095

8. Recyclable BINOL–quinine–squaramide as a highly efficient organocatalyst for α-amination of 1,3-dicarbonyl compounds and α-cyanoacetates, Yongzhi Gao, Bin Liu, Hai-Bing Zhou, Wei Wang, Chune Dong*, RSC Advances, 2015, 31(5), 24392-24398,

9. Synthesis and SARs of indole-based α-amino acids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors, Xin Han, Haoming Wu, Wei Wang, Chune Dong, Po Tien, Shuwen Wu*, Hai-Bing Zhou*, Organic Biomolecular Chemistry, 2014, 41(12), 8308-8317,

10.(3+2) Annulation of Amidinothioureas with Binucleophile: Synthesis and Antimicrobial Activity of 3-Phenylamino-5-aryl/alkyl-1,2,4-oxadiazole Derivatives, Swapnil G. Yerande, Amruta B. Ghaisas, Kiran M. Newase, Wei Wang, Kan Wang, Alexander Dömling, Journal of Heterocyclic Chemistry, 2014, 51(6), 1752-1756

11.Mercury(II) Chloride-Mediated Desulphurization of Amidinothioureas: Synthesis andAntimicrobial Activity of 3-Amino-1,2,4-triazole Derivatives, Swapnil G. Yerande, Chetna D. Baviskar, Kiran M. Newase, Wei Wang, Kan Wang, Alexander Dömling, Journal of Heterocyclic Chemistry, 2014, 51(6), 1883-1887

12.Enantioselective inhibition of reverse transcriptase (RT) of HIV-1 by non racemic indole-based trifluoropropanoates developed by asymmetric catalysis using recyclable organocatalystsXin Han, Wenjie Ouyang, Bin Liu, Wei Wang*, Bo Tian , Shuwen Wu *, Hai-Bing Zhou*, Organic Biomolecular Chemistry,  2013, 2013, 11, 8463-8475

13.N-Butyl-2,4-dinitro-anilinium p-toluenesulfonate as a highly active and selective esterification catalyst, Narsimha Sattenapallya, Wei Wang, Huimin Liu, and Yong Gao*, Tetrahedron Letters2013, 54(48), 6665-6668

14.Esterification Catalysis by Pyridinium p-Toluenesulfonate Revisited Modification with a Lipid Chain for Improved Activities and Selectivities, Wei Wang, Huimin Liu, Shaoyi Xu, and Yong Gao, Synthetic Communications, 2013, 43(21), 2906-2912

15.    P53-Mdm2 Active Benzimidazol-2-onesWei Wang, Haiping Cao, Siglinde Wolf, Miguel S. Camacho-Horvitz, Tad Holak, and Alexander Dömling, Bioorganic & Medicinal Chemistry, 2013, 21, 14, 3982-3995

16.  Chemisty & Biology of Multicomponent Reactions, Alexander Dömling, Wei Wang#, Kan Wang# , (equally contribution) Chemical Reviews, 2012, 112 (6), pp 3083–3135

17.Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein AntagonistsD. Koes, K. Khoury, Y. Huang, Wei Wang, M. Bista, G. M. Popowicz, S. Wolf , T. A. Holak, A. Dömling, C.J. Camacho, Plos One, 2012 , 7(3), e32839

18.  Polycyclic Compounds by Ugi−Pictet−Spengler Sequence, Wei Wang, Sarah Ollio, Alexander Dömling, The Journal of Organic Chemistry, 2011, 76 (2), 637–644, (Selected by Synfact, 2011, 4, 376)

19.Two Strategies for the Development of Mitochondrial-Targeted Small Molecule Radiation Damage Mitigators,  Jean-Claude M. Rwigema,  Barbara Beck, Wei Wang, Alexandaer Doemling, Michael W. Epperly, Donna Shields,  Darcy Franicola,  Tracy Dixon, Marie-Celine Céline Frantz, Peter Wipf,  Yulia Tyurina,  Valerian Kagan, Hong Wang, and Joel S. Greenberger, International Journal of Radiation Oncology*Biology*Physics, 2011, 80(3), 860-868

20. Structures of Low Molecular Weight Inhibitors Bound to MDMX and MDM2 Reveal New Approaches for p53-MDMX/MDM2 Antagonist Drug Discovery, G. M. Popowicz, A. Czarna, S. Wolf, K. Wang, Wei Wang, A. Dömling, T. A. Holak, Cell Cycle, 2010, 9(6), 1104 – 1111.

21. Polycyclic indole alkaloid-type compounds by MCRWei Wang, Eberhardt Herdtweck , Alexander Dömling, Chemical Communications2010, 46, 770-772.

22.   Bacillamide C and Derivatives: The Convergent ApproachWei Wang, Shannon Joyner, Kareem Andrew Sameer Khoury, Alexander Dömling, Organic Biomolecular Chemistry2010, 8, 529-532.

23.    Rapid and efficient hydrophilicity tuning of p53/MDM2 antagonists, Stuti Srivastava, Barbara Beck, Wei Wang, Ania Czarna, Tad Holak, Alexander Dömling, Journal of Combinatorial Chemistry2009, 11 (4), pp 631–639

24. Efficient Synthesis Of Arrays Of Amino Acid Derived Ugi Products With Subsequent Amidation, Wei Wang, Alexander Dömling, Journal of Combinatorial Chemistry2009, 11 (3), p 403-409

25. A Fast and Efficient Approach to Small Molecular Weight Protein-Protein Interaction Antagonists Using MCR ChemistryBarbara Beck, Stuti Srivastava, Wei Wang, Kan Wang, Anna Czarna, Tad A. Holak, Lidio Meireles, Carlos Camacho, Balu Raghavan, Billy W. Day and Alexander Dömling, In MCR 2009; Mironov, M. A., Ed.; Advances in Experimental Medicine and Biology2011, Volume 699, 82.

26.    Progress in biscalixarene research, Zheng, Qin; Gong, Shuling.; Zhang, Chunlei; Wang, Wei; Chen, Yuanyin, Progress in Chemistry (In Chinese) 2007, 19, (5), 722-734,.

27. The Effect of Hydrogen bonds in the Reaction of Phenols with Epoxy in the Presence of Nano CaCO3,Wei Wang, Shuling Gong*, Yuanyin Chen, Supramolecular Chemistry2006, 18(4)311-315.

28. Fibriform One-dimentional Hydrogen-bonded Network Composed of 1,2-alt Calix[4]arene Tetra Acetic AcidWei Wang, Shuling Gong*, Yuanyin Chen, Jianpin Ma, New Journal of Chemistry, 2005, 29:1390-1392.

29.    Preparation and Characterization of Biscalix[4]arene with Alkyne-containing SpacerWang Wei, Gong Shuling, Meng Lingzhi, Chen Yuanyin*, Chemical Journal of Chinese Universities, 2005, 26(8): 1467-1470. (In Chinese)

30.Solid-Phase Microextraction of Aromatic Amines with Amide Bridged Calix[4]arenes Coated FiberWei Wang, Shuling Gong*, Qihua Cao, Yuanyin Chen, Xiujuan Li, and Zhaorui Zeng, Chromatography, 61(1-2):85-80 2005.

31.    Diamide bridged calix[8]arenes, Li Jun, Wang Wei, Gong Shuling, Chen Yuanyin*, Wu Xiaojun, Synlett, 2004, (2): 332-334.

32. Characteristics and Applications of Amide Bridged Calix[4]arene Solid-Phase Microextration Fiber, Xiujuan Li, Shuling Gong, Wei Wang, Zhaorui Zeng*, Chinese Journal of Chromatography, (In Chinese),   2004, 22(5) 472-475 

33.Nano CaCO3: An unique condensation agent for the preparation of monosubstituted calix[4]arene by ring-opening reaction, Gong SL*, Wang Wei, Fang Pengfei, Chen Yuanyin, Chinese Chemical Letters, 2003, 14 (1): 20-21 JAN.

34. Nano CaCO3: playing a special role in the monofunctionalization of calixarenes by epoxides, Gong SL*, Wang Wei, Chen Yuanyin, Meng Lingzhi, Wan Tao, New Journal of Chemistry, 2002, 26 (12): 1827-1830.

35.Novel fiber coated with amide bridged-calix[4]arene used for solid-phase microextraction of aliphatic amines,  Xiujuan Li, Zhaorui Zeng*, Jingjing Zhou, Shuling Gong, Wei Wang, Yuanyin Chen, Journal of Chromatography A, 2004, 1041(1-2): 1-9.



       专利申请授权情况:

ZL 201410147716.4, 201510046379.4, ZL 201510133908.4, 201510915809.1, 201511027501.X, 201611177580.7


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