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刘 鹏

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刘鹏.png

姓名:刘鹏
性别:男
职务/职称:副教授
通讯地址:武汉大学药学院,湖北省武汉市武昌区东湖路185

办公地址:武汉大学东湖路185号武汉大学医学部5号楼10楼
邮编:430071
Email: liupenghk@gmail.com 
电话:

学习与工作简历

2010-至今 武汉大学药学院
2009-2010 
香港大学 研究助理
2004-2008 
香港大学 博士
2003-2004 
香港大学 研究助理
2000-2003
 兰州大学 硕士
1996-2000 
兰州大学 学士

研究领域:

1. 抗病毒,抗肿瘤药物及前体药物的设计、合成与开发。

2. 具有生物活性的杂环化合物的合成方法研究。

承担科研课题:

1 主持武汉大学引进人才科研启动经费,2013.1 – 2015.12;

2 国家自然科学青年基金,2012.1-2014.12

代表论文:

1.       Dingshan Zhou, Wei Tuo, Hao Hu, Jianrong Xu, Hongzhuan Chen, Zhigang Rao, Yuling Xiao, Xianming Hu, Peng Liu*. Synthesis and activity evaluation of tilorone analogs as potential anticancer agents.European Journal of Medicinal Chemistry, 2013, 64, 432-441.

2.       Yungen Liu, Xiangguo Guan, Ella Lai-Ming Wong, Peng Liu, Jie-Sheng Huang, and Chi-Ming Che. Nonheme Iron-Mediated Amination of C(sp3)−H Bonds. Quinquepyridine-Supported Iron-Imide/Nitrene Intermediates by Experimental Studies and DFT Calculations. J. Am. Chem. Soc., 2013, 135, 7194.

3.       Peng Liu, Yuxi Li, Haiyu Wang, Zhiming Wang, Xianming Hu. Synthesis of substituted quinolines by iron catalyzed oxidative coupling reactions. Tetrahedron Letters, 2012, 53, 6654-6656.

4.       Hao Hu, Zhigang Rao, Jianrong Xu, Qingfu Zhu, Hans-Josef Altenbach, Hongzhuan Chen, Dingshan Zhou, Yuling Xiao, Xianbing Ke, Hao Guo, Zhongyuan Wu, Peng Liu*, Xianming Hu. 16-Morpholino quaternary ammonium steroidal derivatives as neuromuscular blocking agents: synthesis, biological evaluation and in silico probe of ligand-receptor interaction. European Journal of Medicinal Chemistry, 2012, 332-347.

5.       Peng Liu, Zhiming Wang, Jue Lin, Xianming Hu. An Efficient Route to Quinolines and Other Compounds by Iron Catalyzed Cross-Dehydrogenative Coupling Reactions on Glycine Derivatives. European Journal of Organic Chemistry 2012, 1583-1589.

6.       Peng Liu, Zhiming Wang, Xianming Hu. Highly Efficient Synthesis of Ureas and Carbamates from Amides by Iodosylbenzene Induced Hofmann Rearrangement. European Journal of Organic Chemistry 2012, 1994-2000.

7.       Peng Liu, Yungen Liu, Ella Lai-Ming Wong, Song Xiang, Chi-Ming Che. Iron Oligopyridine Complexes as Efficient Catalysts for Practical Oxidation of Arenes, Alkanes, Tertiary Amines and N-Acyl Cyclic Amines with Oxone. Chemical Science 20112, 2187-2195.

8.       Hao Guo, Guolan Zhang, Tao Zhang, Xianran He, Zhongyuan Wu, Yuling Xiao, Yuanhu Pan, Guofu Qiu,Peng Liu, Xianming Hu. Synthesis, characterization and biological evaluation of some 16β-azolyl-3β-amino-5α-androstane derivatives as potential anticancer agents. European Journal of Medicinal Chemistry 2011, 9, 3662-3674.

9.       Peng Liu, Cong-Ying Zhou, Song Xiang, Chi-Ming Che. Highly Efficient Oxidative Carbon-Carbon Coupling with SBA-15-Supported Iron Terpyridine Catalyst. Chemical Communications 2010, 46, 2739-2741.

10.   Peng Liu, Ella Lai-Ming Wong, Angella Wing-Hoi Yuen, Chi-Ming Che. Highly Efficient Alkene Epoxidation and Aziridination Catalyzed by Iron(II) Salt +4,4′,4′′-Trichloro-2,2′:6′,2′′-terpyridine/4,4′′-Dichloro-4′-O-PEG-OCH3-2,2′:6′,2′′-terpyridine. Organic Letters 2008, 10, 3275-3278.

11.    Wing-Kei Chan, Peng Liu, Man-Kin Wong, Chi-Ming Che. Highly Diastereoselective Epoxidation of Allyl-Substituted Cycloalkenes Catalyzed by Metalloporphyrins. Organic Letters 2004, 6, 1597-1599.


授权专利:

1. 胡先明,郭豪,刘鹏,16-唑取代-3胺取代-5α雄甾烷衍生物及其制备方法和应用,专利号:ZL201110050236.2.


申请专利:

1. 胡先明,郭豪,刘鹏,16-取代-3杂环-5a雄甾烷衍生物及其制备方法和应用,申请号:201110050268.2

2. 胡先明,肖玉玲,周小菊,刘鹏,茯苓三萜在制备保肝护肝药物上的应用,申请号:201110433742.X

3. 胡先明,汪志明,刘鹏,一种1,3-二取代脲和氨基甲酸酯简便高效的合成方法,申请号:201110358701.9

4. 胡先明,胡昊,饶志刚,刘鹏,肖玉玲,3,16β-二胺基甾体季铵盐衍生物及其制备方法和应用,申请号:201210151149.0

5. 胡先明,胡昊,饶志刚,刘鹏,肖玉玲,4, 16β-二胺基甾体季铵盐衍生物及其制备方法和应用,申请号:201210151370.6


国际国内学术会议及报告:
1. 2012年8月, 第八届世界华人药物化学研讨会分会报告, Design, synthesis and in vivo neuromuscular blocking activity of aminosteroid derivatives


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