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周小菊

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姓名:周小菊                                        

性别:女

职务/职称副教授

通讯地址(含邮编):武汉市武昌区东湖路185号 武汉大学药学院 430071

Email: xjzhou@whu.edu.cn

学习简历:

1994.9 - 1998.6 同济医科大学药学院药学专业,获理学学士学位

2001.9 - 2004.6 华中科技大学同济医学院药学院,获药剂学理学硕士学位

2005.9 - 2008.12 武汉大学化学与分子科学学院,获有机化学博士学位


工作简历:

1998.7 - 2001.8 武汉瑞德生物制品有限公司从事质检工作,执业药师

2004.7 - 至今   武汉大学药学院从事药剂学专业的教学科研工作

2011.6 - 2012.6 美国俄亥俄州立大学药学院从事药剂学博士后研究


研究领域: 药剂学,高分子材料学


研究兴趣与方向:

新型靶向递药系统,新药开发,智能纳米载体材料的研制


承担课题与经费:

1) 主持国家自然科学基金青年基金项目(No.81402882, 2015 - 2017

2) 主持中央高校专项科研基金项目(No.3082035

3) 参与国家自然基金四项(No.2057505029721218127336381571811)

4) 参与武汉市应用基础研究计划项目一项


教学情况:

主讲本科生课程药剂学,生物药剂学与药物动力学


主要科研成果:

论文

1) Xiaoju Zhou*,1, Pengyu Wang1, Jiong Wang, Zhi Liu,Xuechuan Hong, Yuling Xiao, Peng Liu, Xianming Hu. Hydroxyethyl Pachyman as a novel excipient for sustained-release matrix tablets. Carbohydrate Polymers, 2016, 154:1-7.

2) Zhigang Rao, Hao Hu, Jiazhi Tang, Zhiying Liu, Yue Yang,  Guofu Qiu, Yuling Xiao, Peng Liu, Xiaoju Zhou*, Xuechuan Hong*. Steroidal ammonium compounds as new neuromuscular blocking agents. Chemical Biology & Drug Design, 2016, 8: 73-783

3) Zhiming Wang, Jinpin Li, Xiao dong Zeng, Xianming Hu, Xiaoju Zhou,* Xuechuan Hong*. Synthesis and pharmacological evaluation of novel benzenesulfonamide derivatatives as potential anticonvulsant agents.Molecules, 2015, 20(9): 17585-17600.

4) Jing Chen, Ju Zhang, Yanxia Xiang, Limin Xiang, Xiangjiu He, Yongmei Liu, Xiaoju Zhou, Xin Liu, Zebo Huang. Extract of Tsai Tai (Brassica chinensis): Enhanced Antioxidant Activity and Anti-aging Effects both in vitro and in Caenorhabditis elegans. Food & Function, 2016, 7(2): 943-952.

5) Li-Ping Yang, Fang-Jie Jiang, Gui-Sheng Wu,  Ke Deng,  Meng Wen, Xiaoju Zhou, Xuechuan Hong,  Michael X. Zhu, Huai-Rong Luo*. Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice. PLOS ONE, 2015, DOI:10.1371/journal.pone.0136255.

6Xiaoju Zhou, Jiong Wang, Jianhong Wu, Xiaojuan Yang, Bryant C. Yung, L. James Lee, Robert J. Lee*. Preparation and evaluation of a novel liposomal formulation of cisplatin. European Journal of Pharmaceutical Sciences2015, 66: 90-95.

7Mengzi Zhang, Xiaoju Zhou, Bo Wang, Bryant C. Yung , Ly J. Lee, Kalpana Ghoshal, Robert J. Lee*. Lactosylated gramicidin-based lipid nanoparticles (Lac-GLN) for targeted delivery of anti-miR-155 to hepatocellular carcinoma. Journal of controlled release2013, 168: 252-261.

8)Xiaoju Zhou1, Mengzi Zhang1, Hong Li, Chenguang Zhou, Robert J. Lee*. Liver targeting and antitumor activity of doxorubicin liposomes modified with a novel galactosylated lipid. International Journal of Nanomedicine2012, 7: 5465–5474.

9Xiaoju Zhou, Bryant Yung, Hong Li, Xianming Hu, Robert J. Lee*. A novel liposomal gefitinib formulation.Anticancer Research, 2012, 32(7): 2919-23.

10Xiaoju Zhou, Yan Hu, Yanping Tian, Xianming Hu*. Effect of N-trimethyl chitosan enhancing the dissolution properties of lipophilic drug cyclosporin A. Carbohydrate Polymers2009, 76(2): 285-290.

11Yan Hu, Xiaoju Zhou, Yong Lu, Chengyang Hu, Xianming Hu. Novel biodegradable hydrogels based on pachyman and its derivatives for drug delivery. International Journal of Pharmaceutics, 2009, 371: 89-98.

12Xiaoju Zhou, Yimu Yi, Wan Jing, Xianming Hu*. Preparation and body distribution of freeze-dried powder of ursolic acid phospholipid nanoparticles. Drug Development and Industrial Pharmacy20089(16): 1- 6.

13)王炯,周小菊(通讯作者),胡先明. 甘草次酸固体脂质纳米粒的制备及体外性能评价[J],中国药房,2012,23(15): 1364 - 1366.

专利

1周小菊,王炯,胡先明甘草次酸固体脂质纳米及其制备方法专利申请号:201110425597.0.

2周小菊,李剑光,赵孝斌.一种新型铂类脂质体制剂及其制备方法,专利申请号: 201210281809.7.

3) 胡先明周丁山庹伟刘鹏肖玉玲周小菊. 7,4’–二取代异黄酮衍生物及其制备方法与应用专利号:CN201310081701.8.

4) 胡先明周丁山庹伟刘鹏肖玉玲周小菊. 2,7–二取代芴酮衍生物及其制备方法与应用专利号:CN201310081886.2.

5) 胡先明,肖玉玲,段小六,周小菊刘华华活性羧甲基茯苓多糖及其生产工艺和应用专利号:CN200910273267.7.


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