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沈 坤

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沈坤.png

姓名:沈坤

性别:男

职务/职称:副研究员

通讯地址:武汉大学药学院,武汉市武昌区东湖路185号,邮编430071

Emailkun.shen@whu.edu.cn

学习简历:

2008.9 – 2013.7  中国科学院上海有机化学研究所,理学博士

2004.9 – 2008.6  武汉大学化学与分子科学学院,理学学士

工作简历:

2018.9至今     武汉大学药学院,副研究员

2013.8 – 2018.7  美国杜克大学化学系,博士后

研究领域:

有机化学,药物化学,化学生物学

研究兴趣与方向:

1. 合成方法学,手性药物与天然产物的不对称合成

2创新药物的研究与开发

3药物分子作用机制研究

科研成果(至少应有近五年的代表性成果):

1.      Shen, K.; Wang, Q.* “Copper-Catalyzed Alkene Aminoazidation as a Rapid Entry to 1,2-Diamines and Installation of an Azide Reporter onto Azahetereocycles.” J. Am. Chem. Soc. 2017139, 1311013116.

2.      Shen, K.;# Logan, A. W. J.;# Colell, J. F. P.;# Bae, J.; Ortiz, G. X.; Theis, T.; Warren, W. S.;* Malcolmson, S. J.;* Wang, Q.* “Diazirines as Potential Universal Molecular MRI Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization.” Angew. Chem. Int. Ed. 201756, 12112–12116. (Selected as Very Important Paper and Highlighted on Front Cover.)

3.      Shen, K.; Wang, Q.* “Copper-Catalyzed Aminoalkynylation of Alkenes with Hypervalent Iodine Reagents.” Chem. Sci. 20178, 8265–8270.

4.      Hemric, B. N.; Shen, K.; Wang, Q.* “Copper-Catalyzed Amino Lactonization and Amino Oxygenation of Alkenes Using O-Benzoylhydroxylamines.” J. Am. Chem. Soc. 2016138, 58135816.(Highlighted in Synfacts.)

5.      Shen, K.; Wang, Q.* “Copper-catalyzed Aminotrifluoromethylation of Alkenes: A Facile Synthesis of CF3-Containing Lactams.” Org. Chem. Front. 20163, 222226.

6.      Shen, K.; Wang, Q.* “Copper-Catalyzed Diamination of Unactivated Alkenes with Hydroxylamines.”Chem. Sci. 20156, 42794283.

7.      Shen, K.; Han, X.;* Lu, X.* Hu, Z. “Cationic Pd(II)-Catalyzed Arylative Cyclization of 1,6-Enynes with Arylboronic Acids.” Tetrahedron Lett. 201758, 3768–3771.

8.      Shen, K.; Han, X.;* Xia, G.; Lu, X.* “Cationic Pd(II)-Catalyzed Cyclization of N-tosyl-aniline Tethered Alkynyl Ketones Initiated by Hydropalladation of Alkynes: A Facile Way to 1,2-Dihydro- or 1,2,3,4-Tetrahydroquinoline Derivatives.” Org. Chem. Front. 20152, 145149. (HOT articles in Organic Chemistry Frontiers in 2015 and Celebrateing the 80th Birthday of Professor Ei-ichi Negishi.)

9.      Shen, K.; Han, X.;* Lu, X.* “Cationic Palladium(II)-Catalyzed Reductive Cyclization of Alkyne-Tethered Ketones or Aldehydes Using Ethanol as Hydrogen Source.” Org. Lett. 201315, 17321735.

10.  Shen, K.; Han, X.;* Lu, X.* “Cationic Palladium(II)-Catalyzed Highly Enantioselective Arylative Cyclization of Alkyne-Tethered Enals or Enones Initiated by Carbopalladation of Alkynes with Arylboronic Acids.” Org. Lett. 201214, 17561759.



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