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董春娥

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        董春娥,2000年毕业于中国科学院成都有机化学研究所有机化学专业,获理学博士学位。2000年至2001年维也纳大学有机化学研究所博士后。2002年至2004年加拿大渥太华大学化学系博士后。2004年至2006年美国伊利诺伊大学香槟分校化学系博士后。

目前主要研究兴趣:

   1) 具有潜在药物活性小分子的新法合成研究。

   2) 有机化学新方法研究,特别是碳-杂键的构键以及不对称催化研究。

   3) 生物模拟离子通道的设计合成和活性研究。

在研科研项目及经费:

   1)主持国家自然科学基金面上项目(NO: 20972121),2010.1-2012.12,30万。

   2)主持武汉大学引进人才科研启动基金(NO: 306276315),2007.12 -2010.12,10万。

   3)高等学校博士点新教师基金,2010,1-2012,12, 3.6万。

   4)教育部留学回国基金,3万

   5)病毒学重点实验室开放基金,2011,3-2012-12,3万。

   6)药物中间体的研发,25万。


代表性文章:

(1) Xin Han, Xiangfei Wu, Chang Min, Hongyu Zhu, Haibing Zhou, Chune Dong*, An Expedient Approach to Highly Enantioenriched Cyclic Nitrones Mediated by Robust and Recoverable C3-Symmetric Cinchonine-Squaramide Catalyst, RSC Advance 2012, 2, 7501-7505.

(2) Zongquan Liao, Xiaoyan Xu, Hai-Bing Zhou, Chune Dong*, A New Pathway for Phthalazine Derivatives via Metal-free Cyclization of ortho-Alkynylphenyl ketones and Hydrazine, J. Heterocycl. Chem., 2013, in press.

(3) Hao Chen, Jianmin Wang, Xuechuan Hong, Haibing Zhou, Chune Dong*, A simple and straightforward approach toward selective C=C bond reduction by hydrazine, Can. J. Chem., 2012, 90, 758-761.

(4) Xin Han, Bin Liu, Hai-Bing Zhou, Chune Dong*, Enhanced efficiency of recyclable C3-symmetric cinchonine-squaramides in the asymmetric Friedel-Crafts reaction of indole with alkyl trifluoro pyruvate, Tetrahedron: Asymmetry, 2012, 23, 1332-1337.

(5) Ze Dong, Guofu Qiu, Hai-Bing Zhou, Chune Dong*, Chiral Squaramide as Multiple H-Bonds Donor Organocatalyst for Asymmetric Michael addition of 1, 3-Dicarbonyl Compounds to Nitroolefins, Tetrahedron: Asymmetry, 2012, 23, 1550-1556.

(6) Pengcheng Wang, Jian Min, Jerome C. Nwachukwu, Valerie Cavett, Kathryn E. Carlson, Pu Guo, Manghong Zhu, Yangfan Zheng, Chune Dong, Haibing Zhou*, Identification and structure-Activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2,2,1]hept-2-ene-7-oxide, J. Med. Chem., 2012, 55 (5), 2324–2341.

(7) Chang Min, Xin Han, Zong quan Liao, Xiangfei Wu, Haibing Zhou, Chune Dong*, C3-symmetric cinchonine-squaramide as new highly efficient and recyclable organocatalyst for enantioselective michael addition, Adv. Syn. Cat. 2011, 353, 2715-2720. Highlighted by ChemInform (2012, 43, 13).

(8) Xiangfei Wu, Chang Min, Enkhtsetseg Nyamzundui, Haibing Zhou, Chune Dong*, A Novel C3-Symmetric Prolinol-Squaramide Catalyst for the Asymmetric Reduction of Ketones by Borane, Tetrahedron: Asymmetry, 2011, 22, 1640-1643.

(9) Ze Dong, Xiao qing Jin, Peng cheng Wang, Chang Min, Haibing Zhou, Chune Dong*, Novel bifunctional chiral squaramide-amine catalysts for highly enantioselective addition of mono diketones to nitroalkenes, Arkivoc 2011, (ix), 367-380.

(10) Chune Dong*, Lingli Xie, Xiaohong Mou, Yashan zhong, Wei Su, Facile synthesis of 1,3,4-benzotriazepines and 1-arylamide-1H-indazoles via palladium catalyzed cyclization of aryl isocyanates and aryl hydrazones under microwave irradiation, Org. Biomol. Chem. 2010, 8, 4827-4830. Highlighted by Synfacts (2011, 1, 16).

(11) Yangfan Zheng, Caihua Wang, Changhao Li, Jinxia Qiao, Feng Zhang, Minjian Huang, Chune Dong, Jian Huang, HaiBing Zhou, Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo [2.2.1]hepte-ne scaffold and evaluation of their antiproliferative effects, Org. Biomol. Chem. 2012, 10, 9689-9699.

 (12) Manghong Zhu, Chen Zhang, Jerome C. Nwachukwu, Yangfan Zheng, Chune Dong, John A. Katzenellenbogen, Kendall W. Nettles, Haibing Zhou*, Biocyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfon-amides, Org. Biomol. Chem. 2012, 10, 8692-8700.

(13) Yangfan Zheng, Manghong Zhu, Sathish Srinivasam, Jerome C. Nwachukwu, Valerie Cavett, Jian Min, Kathryn, E. Carlson, Pengcheng Wang, Chune Dong, John A. Katzenelle-nbogen, Kendall W. Nettles, Haibing Zhou*, Development of selective estrogen receptor modulator SERM-like activity through an indirect mechanism of estrogen receptor antagonism defining the binding mode of 7-oxabicyclo[2.2.1] hept-5-ene scaffold core ligands, ChemMedChem. 2012, 7, 1094-1100.

 (14) Jian Min, Pengcheng Wang, Chune Dong, Haibing Zhou*, Progress in small molecular inhibitors of protein protein interactions, Chin. J. Org. Chem. 2010, 30, 1778-1789.


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