当前位置:首页 >> 师资队伍 >> 教授

洪学传

来源:admin  浏览量:  更新时间:2018-11-06 10:17:38

洪学传.png

洪学传

职称:教授

学历:博士研究生

通讯地址:武汉大学药学院5号楼1002

电话:027-68759734         邮编:430071

电子邮件:Xhy78@whu.edu.cn

 

教育经历

2001.012005.07  美国密苏里大学哥伦比亚分校化学系,研究生,博士学位

1997.091999.11  天津大学化工学院,研究生,硕士学位

1993.091997.07  天津大学应用化学系,本科,学士学位

1993.091997.07  天津大学管理学院技术经济学系,本科,学士学位

 

工作经历

2017.12 至今  西藏大学医学院教授,博士生导师

2010.10 至今  武汉大学药学院教授,博士生导师

湖北省“楚天学者”特聘教授

武汉市 “黄鹤英才”人才计划

武汉大学珞珈学者特聘教授

2007.102010.10  美国 AMRI,资深研究员

2005.092007.09  美国爱默里大学化学系,博士后研究员

1999.122000.07  日本北海道大学,药学院,研修生

 

学术兼职

《中国药物化学杂志》编委

Wuhan University Journal of Natural Sciences》编委

Chinese Chemical Letters》青年编委

《医药导报》编委

全国卫生产业企业管理协会精准医疗分会理事

中国生物化学与分子生物学会蛋白质组学专业理事

中国生物物理学会分子影像学专业委员会委员

中国医药生物技术协会药物分析技术分会委员

中国药理学学会分析药理学专业委员会委员

湖北省中小企业共性技术药物及药用材料研发推广中心主任

湖北省科技进步促进会常务理事

 

研究内容

近红外二区有机小分子探针的制造,可视化肿瘤、病毒感染机制研究及药物开发

 

科研项目

 

1)    动脉粥样硬化斑块的NIRF-II/MRI双模态分子成像研究(81773674),国家自然基金委面上项目,2018.01-2021.12,主持

2)    近红外II区小分子探针的构建及肿瘤手术导航研究(JCYJ20170303170809222),深圳市知识创新计划基础研究项目,2018.01-2020.012 ,主持

3)    乳腺癌靶点小分子精准调控及诊疗一体化研究(2017CFA024),湖北省自然科学基金创新团队,2017.08-2020.07 ,主持

4)    uPAR受体靶向的新型双模态分子探针的研制及显像研究(81573383, 国家自然基金委面上项目,2016.01-2019.12 ,主持

5)    具有神经营养活性的石蒜科生物碱的合成及活性机制研究(81373254),国家自然基金委面上项目,2014. 01-2014.12 ,主持

6)    过渡金属催化的C-H键活化和高效转化的基本科学问题(21390402),国家自然基金委重大项目,2014.01-2018.12,第一参与

7)    帐篷系统污水的病毒灭活剂研究(2012ZX10004801-003-011),卫生部国家科技重大专项(艾滋病和病毒肝炎等重大传染病防治)2012.01-2015.12 ,子课题

 

成果

1.      Bingbing Ding, Yuling Xiao,Hui Zhou, Xiao Zhang, Chunrong Qu, Fuchun Xu, Zixin Deng, Zhen Cheng, Xuechuan Hong*, Polymethine thiopyrylium fluorophores with absorption beyond 1000 nm for biological imaging in the second near-infrared sub-window. J. Med. Chem. 2019, 62, 2049−2059. 2区,IF= 6.05(Highlighted by Synfact)

2.       Chunrong Qu, Mingmin Ding, Yingmin Zhu, Yungang Lu, Juan Du, Melissa R. Miller, Jinbin Tian, Jinmei Zhu, Jian Xu, Meng Wen, AGA Er-Bu, Jule Wang, Yuling Xiao, Meng Wu, Owen B. McManus, Min Li, Jilin Wu, Huai-rong Luo, Zheng-yu Cao, Bing Shen, Hongbo Wang*, Michael X. Zhu*, Xuechuan Hong*Pyrazolopyrimidines as potent stimulators for transient receptor potential canonical 3/6/7 channels. J. Med. Chem. 2017, 60(11), 4680−4692. (Cover Paper) 2区,IF= 6.05

3.       Alexander L. Antaris, Hao Chen, Kai Cheng, Yao Sun, Guosong Hong, Chunrong Qu, Shuo Diao, Zixin Deng, Xianming Hu, Bo Zhang, Xiaodong Zhang, Omar K. Yaghi, Zita R. Alamparambil, Xuechuan Hong*, Zhen Cheng* and Hongjie Dai*. A small molecule dye for NIR II imaging. Nat. Mater. 2016, 15(2), 235–242. (ESI 高被引) 1区,IF=39.8

4.       Yao Sun, Xiaowei Ma, Kai Cheng, Biying Wu, Jianli Duan, Hao Chen, Lihong Bu, Ruiping Zhang, Xianming Hu, Zixin Deng, Lei Xing, Xuechuan Hong*, Zhen Cheng*. Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes. Angew. Chem. Int. Ed. 2015, 54(20), 5981-5984. (Hot Paper) 1区,IF=12.2

5.       Alexander L. Antaris,, Hao Chen, Shuo Diao, Zhuoran Ma, Zhe Zhang, Shoujun Zhu, Joy Wang, Alexander Lozano, Quli Fan, Leila Chew, Mark Zhu, Kai Cheng, Xuechuan Hong*, Hongjie Dai*, Zhen Cheng*, A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging. Nat. Commun. 20178,15269. (ESI 高被引)1区,IF=11.9

6.       Yao. Sun, Xiaodong Zeng, Yuling Xiao, Changhao Liu, Hua Zhu, Hui Zhou, Ziyang Chen, Fuchun Xu, Jule Wang, Mengyue Zhu, Junzhu Wu, Zixing Deng, Zhen Cheng*, Xuechuan Hong*, Dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery. Chem. Sci. 2018, 9, 2092–2097.1区,IF=9.56 ESI 高被引)

7.       Jiacheng Lin, Xiaodong Zeng, Yuling Xiao, Lin Tang, Jinxia Nong, Yufang Liu, Hui Zhou, Bingbing Ding, Fuchun Xu, Hanxing Tong, Zixin Deng, Xuechuan Hong* , Novel near-Infrared II aggregation-induced emission dots for in vivo bioimaging . Chem. Sci. 2019, 10, 1219-1126. 1区,IF=9.56

8.       Yao Sun, Mingmin Ding,Xiaodong Zeng, Yuling Xiao, Huaping Wu, Hui Zhou, Bingbing Ding, Chunrong Qu, Wei Hou, AGA Er-Bu, Yejun Zhang, Zhen Cheng , Xuechuan Hong*, Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery. Chem. Sci.  2017, 8, 3489-3493. 1区,IF=9.56

9.       Yao Sun,Chunrong Qu, Hao Chen, Maomao He, Chu Tang, Kangquan Shou, Su Hong, Meng Yang, Yuxing Jiang, Bingbing Ding, YulingXiao, Lei Xing, Xuechuan Hong*Zhen Cheng*Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer, Chem. Sci. 2016, 76203-6207. 1区,IF=9.56

10.     Yao Sun, Suhyun Hong, Xiaowei Ma, Kai Cheng, Jing Wang, Zhe Zhang, Meng Yang, Yuxin Jiang, Xuechuan Hong*, Zhen Cheng*, Recyclable Cu(I)/Melanin dots for cycloadditions, bioconjugation and cell labeling. Chem. Sci. 2016, 75888-5892. (Highlighted by Synfact) 1区,IF=9.56

11.    Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan Li, Yan Li, Haibing Zhou*, Xuechuan Hong*, Zixin Deng, Metal-free direct amidation of peptidyl thiol esters with amino acid esters. Green Chem. 2011, 13, 2723. 1区,IF=9.405

12.    Chunrong Qu, Yuling Xiao, Hui Zhou, Bingbing Ding, Anguo Li, Jiacheng Lin, Xiaodong Zeng, Hao Chen, Kun Qian, Xiao Zhang, Wei Fang, Junzhu Wu, Zixin Deng, Zhen Cheng,* Xuechuan Hong*. Quaternary ammonium salt based NIR-II probes for In vivo imaging. Adv. Optical Mater. 2019, 1900229. 1区,IF=7.125

13.    Hui Zhou, Han Yang, Lin Tang, Yue Wang, Yang Li, Nan Liu, Xiaodong Zeng, Yu Yan, Junzhu Wu, Shizhen Chen, Long Xiao, Yi Yu, Zixin Deng, Hai Deng, Xuechuan Hong, * Yuling Xiao* Mn-loaded apolactoferrin dots for in vivo MRI and NIR-II cancer imaging. J. Mater. Chem. C 2019, 7, 9448-94541区,IF=6.65

14.    Yingmin Zhu, Yungang Lu, Chunrong Qu, Melissa Miller, Jinbin Tian, Dhananjay P Thakur, Jinmei Zhu, Zixin Deng, Xianming Hu, Meng Wu, Owen B McManus, Min Li, Xuechuan Hong*, Michael X Zhu*, Huai-Rong Luo*, Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. 2015, Bri. J. Pharm. 172(14), 3495-3509. 2区,IF=6.58

15.    Mingmin Ding, Hongbo Wang, Chunrong Qu, Fuchun Xu, Yingmin Zhu,  Guangyao Lv, Yungang Lu, Qingjun Zhou, Hui Zhou, Xiaodong Zeng, Jingwen Zhang, Chunhong Yan, Jiacheng Lin, Huai-Rong Luo, Zixing Deng, Yuling Xiao, Jinbin Tian, Michael X. Zhu, Xuechuan Hong*, Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer. Cancer Lett. 2018, 432, 47–55. 1区,IF=6.508

16.    Xiaodong Zeng, Yuling Xiao, Jiacheng Lin, Shanshan Li, Hui Zhou, Jinxia Nong, Guozhen Xu, Hongbo Wang, Fuchun Xu, Junzhu Wu, Zixin Deng, Xuechuan Hong*, Near-Infrared II dye-protein complex for biomedical imaging and imaging-guided photothermal therapy. Adv. Healthcare Mater. 2018, 7, 1800589. 1区,IF=6.27

17.    Xiaodong Zeng,† Ziyang Chen,† Lin Tang,† Han Yang, Nan Liu, Hui Zhou, Yang Li, Junzhu Wu, Zixin Deng, Yi Yu, Hai Deng,* Xuechuan Hong* and Yuling Xiao*. A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection. Chem. Commun. 2019, 55, 2541-2544. 1区,IF= 6.16

18.    Jing Yang, Xuechuan Hong*, New glowing dyes in vivo imaging with wavelengths beyond 1500 nm. Sci. China Chem. 2019, 62(1), 7-8. 2区,IF= 6.08

19.    Jinping Li, Jun Lou, Zhiming Wang, Ting Wang, Yuling Xiao, Xianming Hu, Peng Liu, Xuechuan Hong*, Design, synthesis and pharmacological evaluation of novel N-(2-(1,1-dimethyl-5, 7-dioxo-4, 6-diazaspiro[2.4]heptan-6-yl)ethyl) sulfonamide derivatives as potential anticonvulsant agents. Eur. J. Med. Chem. 2015, 92, 370-376. 2区,IF=4.833

20.     Jun Lou, Xiaoyan Yang, Zhigang Rao,Wenwen Qi, Jinhui Li, HaiyuWang, Yuxi Li, Jinping Li, Zhiming Wang, Xianming Hu, Peng Liu*, Xuechuan Hong*, Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors. Eur. J. Med. Chem. 2014, 83, 466-473. 2区,IF=4.833

 

奖励

 

2018年度西藏大学优秀工作者

2017-2018年度西藏大学医学院优秀论文特别贡献奖

2016年获武汉大学朱裕璧医学奖

2016年武汉大学珞珈学者特聘教授

2016年获武汉大学医学部医学突出贡献奖

2015年获武汉大学医学部医学突出贡献奖

2014年获武汉市第三批“黄鹤英才”人才计划

2014年获美国化学会组织颁发的第九届世界华人药学会最佳报告奖

2011年入选湖北省“楚天学者”特聘教授


上一篇:陈 实
下一篇:没有了