Position: Team Leader of the Research Project/Associate Professor
School/Academic Group: School of Pharmaceutical Sciences
Email: cysh2002@163.com
Education:
2001.09 – 2005.06 Central South University, Bachelor
2007.09 – 2012.06 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Ph.D.
Working Experience:
2012.07 – Present Wuhan University, School of Pharmaceutical Sciences, Lecturer, Associate Professor
2016.01 – 2018.01 University of Hawaii (USA), Postdoc
Current Teaching Interests/Responsibilities:
Experiment of Natural Pharmaceutical Chemistry
Research Interests:
The active natural products of medicinal plants and their activities, the active chemical components of endophytic fungi in plants and marine microorganisms.
Discovery, modification, structure-activity relationship and mechanism research of natural products with anti-tumor, antibacterial and anti-inflammatory activities.
Publications:
[1] Y.-S. Cai, Y.-W. Guo* and K. Krohn. Structure, bioactivities, biosynthetic relationships and chemical synthesis of the spirodioxynaphthalenes. Natual Product Reports, 2010, 27, 1840-1870. (SCI一区, IF: 11.876)
[2] Y.-S. Cai, T. Kurtán, Z.-H. Miao, A. Mándi, I. Komáromi, H.-L. Liu, J. Ding, and Y.-W. Guo*. Palmarumycins BG1-BG7 and preussomerin BG1: establishment of their absolute configurations using theoretical calculations of electronic circular dichroism spectra. The Journal Organic Chemistry. 2011, 76, 1821-1830. (SCI二区TOP, IF: 4.335)
[3] Y.-S. Cai, L.-G. Yao, A. Di Pascale, C. Irace, E. Mollo, O. Taglialatela-Scafati, Y.-W. Guo*. Polyoxygenated diterpenoids of the eunicellin-type from the Chinese soft coral Cladiella krempfi. Tetrahedron 2013, 69, 2214-2219. (SCI三区, IF: 2.233)
[4] L.-F. Liang#, T. Wang#, Y.-S. Cai#, W.-F. He, P. Sun, Y.-F. Li, Q. Huang, O. Taglialatela-Scafati*, H.-Y. Wang*, Y.-W. Guo*. Brominated polyunsaturated lipids from the Chinese sponge Xestospongia testudinaria as a new class of pancreatic lipase inhibitors. European Journal of Medicinal Chemistry. 2014, 79, 290-297. (SCI一区, IF: 5.572)
[5] Z.-F. Zhou, M. Menna, Y.-S. Cai, and Y.-W. Guo*. Polyacetylenes of marine origin: chemistry and bioactivity. Chemical Reviews, 2015, 115 (3), 1543–1596. (SCI一区, IF: 52.758)
[6] Y.-S. Cai, A. M. Sarotti, D. Gündisch, T. P. Kondratyuk, J. M. Pezzuto, J. Turkson, S. Cao*. Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities. Bioorganic & Medicinal Chemistry Letters, 2017, 27, 4630-4634. (SCI三区, IF: 2.572)
[7] S.-Y. Zhou, T.-L. Zhou, G. Qiu, X. Huan, Z.-H. Miao, S.-P. Yang, S. Cao, F. Fan, Y.-S. Cai*. Three new cytotoxic monoterpenoid bisindole alkaloids from Tabernaemontana bufalina. Planta Medica, 2018, 84, 1127-1133. (SCI三区, IF: 2.687)
[8] S.-Y. Zhou, F. Fan, J.-Z. Sun, Z. Guo, W.-T. Sun, L. Chen, Q.-Q. Tang, G. Qiu, S.-P. Yang, J. Yu, Y.-S. Cai*. Cytotoxic alkaloids from the fruits and seeds of Alangium salviifolium (L.f.) Wangerin. Phytochemistry Letters 2018, 26, 195-198. (SCI四区, IF: 1.459)
[9] Y.-S. Cai, J.-Z. Sun, Q.-Q. Tang, F. Fan & Y.-W. Guo*. Acanthiline A, a pyrido[1,2-a]indole alkaloid from Chinese mangrove Acanthus ilicifolius. Journal of Asian Natural Products Research, 2018, 20(11), 1088-1092. (SCI四区, IF: 1.345)
[10] Y.-S. Cai*, A. M. Sarotti, T.-L. Zhou, R. Huang, G. Qiu, C. Tian, Z.-H. Miao, A. Mándi, T. Kurtán, S. Cao,* S.-P. Yang*. Flabellipparicine, a flabelliformide-apparicine-type bisindole alkaloid from Tabernaemontana divaricata. Journal of Natural Products, 2018. 81, 1976-1983. (SCI二区TOP, IF:3.779)
[11] Y.-S. Cai,* C. Wang, C. Tian, W.-T. Sun, L. Chen, D. Xiao, S.-Y. Zhou, G. Qiu, J. Yu, K. Zhu, and S.-P. Yang* Octahydro-protoberberine and protoemetine-type alkaloids from the stems of Alangium salviifolium and their cytotoxicity. Journal of Natural Products, 2019, 82, 2645-2652. (SCI二区TOP, IF:3.779)
[12] Y.-S. Cai,# Z. Wu,# J.-R. Wang, X.-Q. Zheng, J. Xu, G. Qiu, J. Yu*. Spiroalanfurantones A-D, four eudesmanolide-furan sesquiterpene adducts with a pentacyclic 6/6/5/5/5 skeleton from Inula helenium. Organic Letters, 2019, 21, 9478-9482. (SCI一区, IF: 6.091)
[13] Y.-S. Cai,# Z. Wu,# X.-Q. Zheng, C. Wang, J.-R. Wang,c X.-X. Zhang, G. Qiu, K. Zhu, S. Cao and J. Yu*. Spiroalanpyrroids A and B, sesquiterpene alkaloids with a unique spiro-eudesmanolide–pyrrolizidine skeleton from Inula helenium. Organic Chemistry Fronters, 2020, 7, 303-309. (SCI一区, IF: 5.155)
[14] Z. Wu,# Y.-S. Cai,# R. Yuan, Q. Wan, D. Xiao, J. Lei, J. Yu* Bioactive pterocarpans from Trigonella foenum-graecum L. Food Chemistry. 2020, 313, 126092/1-7. (SCI一区, IF: 6.306)
[15] C.-K. Tian, R.-Y. Yuan,* Y.-X. Wang, L. Chen, Z. Wu, L. Liu, Y.-S. Cai* Two new guaiane sesquiterpenes from the fruiting bodies of Lactarius Deliciosus. J. Asian Nat. Prod. Res. 2020, DOI: 10.1080/10286020.2019.1695781. (SCI四区, IF: 1.345)
[16] Y.-S. Cai, J. Xu, M. Chen, D. Wang, Y. Yang, A. Manavalan, X. Wu, Y. Liu,* S. Cao* Compound analysis of Jing Liqueur and nrf2 activation by Jing liqueur-one of the most popular beverages in China. Beverages 2020, 6 (1), 1-18. (SCIE)
[17] Y.-S. Cai, W.-X. Cui, W. Tang, Y.-W. Guo*; Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa. Bioorganic Chemistry 2020, 104, 104167/1-8. (SCI二区TOP, IF: 4.831)
