Position: Associate Professor
School/Academic Group: School of Pharmaceutical Sciences
Email: chenli1012@whu.edu.cn
Education：
2008.09 – 2011.06 Huazhong Agricultural University, College of Life Science and Technology, M.S.
2013.09 – 2018.06 Wuhan University, School of Pharmaceutical Sciences, Ph.D.
2016.11 – 2018.06 Department of Chemistry, Boston University (USA), Joint Ph.D. Training
Working Experience：
2018.07 – 2019.08 The Ohio State University (USA), College of Pharmacy, Postdoc.
2018.07 – 2021.09 Wuhan University, School of Basic Medical Sciences, Postdoc.
2019.09 – 2021.09 University of Chicago (USA), Department of Chemistry, Postdoc.
2021.10 – 2023.09 Wuhan University, School of Pharmaceutical Sciences, Research Assistant
2023.10 – Present Wuhan University, School of Pharmaceutical Sciences, Specially Appointed Associate Researcher
Research Interests:
RNA Chemical Biology: Development of technologies for studying RNA epigenetic modifications.
Molecular Mechanisms of "Longevity Vitamins" in Anti-Aging
Publications：
1. Chen L#, Zhang L-S#, Ye C#, Zhou H, Deng Z, Zhao C*, He C*, Dickinson B* Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2′-O-methylation. Cell Research. 2023. 33(9):727-730.
2. Chen L#, Zhang L#, Ye X, Deng Z*, Zhao C*. Ergothioneine and its congeners: Anti-ageing mechanisms and pharmacophore biosynthesis. Protein and Cell. 2023 Aug 10; pwad048.
3. Zhang Y, Chen L, Wilson J, Cui J, Roodhouse H, Kayrouz C, Pham T, Ju K-S*. Valinophos Reveals a New Route in Microbial Phosphonate Biosynthesis that is Broadly Conserved in Nature. J Am Chem Soc. 2022. 144(22):9938-9948.
4. Chen L#, Naowarojna N#, Chen B, Xu M, Quill M, Wang J, Deng Z, Zhao C*, and Liu P*. Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr). ACS Catal. 2019, 9(1): 253-258.
5. Chen L, Naowarojna N, Song H, Wang S, Wang J, Deng Z, Zhao C*, Liu P*. Use of a Tyrosine Analogue to Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C-S Bond Formation. J Am Chem Soc. 2018. 140(13):4604-4612.
6. Naowarojna N#, Cheng R#, Chen L#, Quill M, Xu M, Zhao C*, Liu P*. Mini-Review: Ergothioneine and Ovothiol Biosynthesis, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis. Biochemistry. 2018. 57(24):3309-3325.
7. Chen L, Li P, Deng Z, Zhao C*. Ornithine Transcarbamylase ArgK Plays a Dual role for the Self-defense of Phaseolotoxin Producing Pseudomonas syringae pv. phaseolicola. Sci Rep. 2015. 5:12892.
8. Chen L, Wang Y, Guo H, Xu M, Deng Z, Tao M*. High-throughput screening for Streptomyces antibiotic biosynthesis activators. Appl Environ Microbiol. 2012. 78(12):4526-4528.
