Position: Associate Professor
School/Academic Group: School of Pharmaceutical Sciences
Email: ZhengL23@whu.edu.cn
Education：
2006.09 – 2010.07 Anhui Agricultural University, College of Life Sciences, B.S. in Biological Sciences
2010.09 – 2015.06 University of Science and Technology of China (USTC), School of Life Sciences, Ph.D. in Biological Sciences
Working Experience：
2017.04 – 2021.11 University of California, Irvine (UCI), School of Medicine, Postdoc
2023.04 – Present Wuhan University, School of Pharmaceutical Sciences, Specially Appointed Associate Researcher
Research Interests:
Pathogenic Microorganisms and Host-Pathogen Interactions; Targeted Drug Discovery
Publications：
1. Liu, Z., Lee, P. G., Krez, N., Lam, K. H., Liu, H., Przykopanski, A., Chen, P., Yao, G., Zhang, S., Tremblay, J. M., Perry, K., Shoemaker, C. B., Rummel, A., Dong, M#. & Jin, R#. (2023) Structure basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2, Nature Communications. 14, 2338.
2. Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M. & Jin, R. (2021) Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B, Science Advances. 43, eabi4582.
3. Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M#. & Li, X#. (2014) Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Nucleic Acids Research. 42, 9470-83.
4. Chen, P*., Tao, L*., Wang, T., Zhang, J., He, A., Lam, K. H., Liu, Z., He, X., Perry, K., Dong, M#. & Jin, R#. (2018) Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B, Science. 360, 664-669.
5. Chen, P*., Zeng, J*., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, R., Huang, L., Dong, M#. & Jin, R#. (2021) Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, Nature Communications. 12, 3748.
6. Chen, P., Lam, K. H., Liu, Z., Mindlin, F. A., Chen, B., Gutierrez, C. B., Huang, L., Zhang, Y., Hamza, T., Feng, H., Matsui, T., Bowen, M. E., Perry, K. & Jin, R. (2019) Structure of the full-length Clostridium difficile toxin B, Nature Structural & Molecular Biology. 26, 712-719.
7. Chen, B., Liu, Z., Perry, K., & Jin, R. (2022) Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition, Scientific Reports. 12, 9028.
8. Chen, P., Tao, L., Liu, Z., Dong, M. & Jin, R. (2019) Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B, FEBS Journal. 286, 874-881.
9. Jahid, S., Ortega, J. A., Vuong, L. M., Acquistapace, I. M., Hachey, S. J., Flesher, J. L., Serra, M. A. L., Brindani, N., Sala, G. L., Manigrasso, J., Arencibia, J. M., Bertozzi, S. M., Summa, M., Bertorelli, R., Armirotti, A., Jin, R., Liu, Z., Chen, C. F., Edwards, R., Hughes, C. C. W., Vivo, M. D. & Ganesan, A. K. (2022) Structure-based design of Cdc42 effector interaction inhibitors for the treatment of cancer, Cell Reports. 39, 110760.
10. Chen, P., Liu, Z., Wang, X., Peng, J., Sun, Q., Li, J., Wang, M., Niu, L., Zhang, Z., Cai, G., Teng, M. & Li, X. (2015) Crystal and EM structures of human phosphoribosyl pyrophosphate synthase I (PRS1) provide novel insights into the disease-associated mutations, PLoS One. 10, e0120304.
