Position: Associate Professor

School/Academic Group:  School of Pharmaceutical Sciences

Email：taoweixin@whu.edu.cn

Education:

2008 - 2011: Dong-A University (Korea), Ph.D.

2003 - 2006: Huazhong Agricultural University, Master

Working Experience:

2014 - Present: Wuhan University, Lecturer, Associate Professor

2011 - 2013: Wuhan University, Postdoc

2006 - 2008: Researcher at National Engineering Research Center of South China Sea Marine Biotechnology, Sun Yat-sen University

Current Teaching Interests/Responsibilities:

Experiment of Biochemistry

Research Interests:

Biosynthesis research and resource mining of microbial natural products under the guidance of genomics

Publications: (# First author, * Corresponding author)

1.Tao WX,* Chen L, Zhao CH, Wu J, Yan DZ, Deng ZX, Sun YH.* 2019. In vitro packaging mediated one-step targeted cloning of natural product pathway. ACS Synth Biol. 8(9):1991-1997.

2.Kong LY,# Xu GD,# Liu XQ, Wang JW, Tang ZL, Cai YS, Shen K, Tao WX, Zheng Y, Deng ZX, Price NPJ, Chen WQ.* 2019. Divergent biosynthesis of C-nucleoside minimycin and indigoidine in bacteria. iScience. 22:430-440.

3.Tao WX, Yang AN, Deng ZX, Sun YH.* 2018. CRISPR/Cas9-based editing of Streptomyces for discovery, characterization and production of natural products. Front Microbiol. 9:1660.

4.Lee MH,# Khan R,# Tao WX,# Choi KH, Lee SY, Lee JW, Hwang EC, Lee SW.* 2018. Soil metagenome-derived 3-hydroxypalmitic acid methyl ester hydrolases suppress extracellular polysaccharide production in Ralstonia solanacearum. J Biotechnol. 270:30-38.

5.Liu YZ, Chen X, Li ZY, Xu W, Tao WX, Wu J, Yang J, Deng ZX, Sun YH.* 2017. Functional analysis of cytochrome P450s involved in streptovaricin biosynthesis and generation of anti-MRSA analogues. ACS Chem Biol. 12(10):2589-2597.

6.Havemann J, Yurkovich ME, Jenkins R, Harringer S, Tao WX, Wen SS, Sun YH, Leadlay PF,* Tosin M.* 2017. Chemical probing of thiotetronate bio-assembly. Chem Commun (Camb). 53:1912-1915.

7.Tao WX,# Yurkovich ME,# Wen SS,# Lebe KE, Samborskyy M, Liu YZ, Yang AN, Liu YK, Ju YC, Deng ZX, Tosin M, Sun YH,* Leadlay PF.* 2016. A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis. Chem Sci. 7:376-385.

8.Liu YK,# Tao WX,# Wen SS, Li ZY, Yang AN, Deng ZX, Sun YH.* 2015. In vitro CRISPR/Cas9 system for efficient targeted DNA editing. mBio. 6:e01714-15.

9.Wu J, Kong HG, Jung EJ, Choi SY, Lee HJ, Tao WX, Chung ES, Lee SW.* 2015. Loss of glutamate dehydrogenase in Ralstonia solanacearum alters dehydrogenase activity, extracellular polysaccharide production and bacterial virulence. Physiol Mol Plant P. 90:57-64.

10.Zhao CH,* Qi JZ, Tao WX, He L, Xu W, Chan J, Deng ZX.* 2014. Characterization of biosynthetic genes of ascamycin/dealanylascamycin featuring a 5’-O-sulfonamide moiety in Streptomyces sp. JCM9888. PloS One. 9(12):e114722.

11.Tao WX,# Zhu MH,# Deng ZX, Sun YH.* 2013. Biosynthesis of tetronate antibiotics: a growing family of natural products with broad biological activities. Sci China Chem. 56:1364-1371.

12.Kanchanabanca C,# Tao WX,# Hong H, Liu YJ, Hahn F, Samborskyy M, Deng ZX, Sun YH,* Leadlay PF.* 2013. Unusual acetylation-elimination in the formation of tetronate antibiotics. Angew Chem Int Edit. 52:5785-5788.

13.Tao WX, Lee MH, Wu J, Kim NH, Kim JC, Chung ES, Hwang EC, Lee SW.* 2012. Inactivation of chloramphenicol and florfenicol by a novel chloramphenicol hydrolase. Appl Environ Microbiol. 78:6295-6301.

14.Tao WX, Lee MH, Yoon MY, Kim JC, Malhotra S, Wu J, Hwang EC, Lee SW.* 2011. Characterization of two metagenome-derived esterases that reactivate chloramphenicol by counteracting chloramphenicol acetyltransferase. J Microbiol Biotechnol. 21:1203-1210.

15.Tao WX, Lee MH, Wu J, Kim NH, Lee SW.* 2011. Isolation and characterization of a family VII esterase derived from alluvial soil metagenomic library. J Microbiol. 49:178-185.

16.Lee MH, Hong KS, Malhotra S, Park JH, Hwang EC, Choi HK, Kim YS, Tao WX, Lee SW.* 2010. A new esterase EstD2 isolated from plant rhizosphere soil metagenome. Appl Microbiol Biotechnol. 88:1125-1134.

17.Li WC,# Wu J,# Tao WX, Zhao CH, Wang YM, HE XY, Chandra G, Zhou XF, Deng ZX, Chater KF, Tao MF.* 2007. A genetic and bioinformatics analysis of Streptomyces coelicolor genes containing TTA codons, possible targets for regulation by a developmentally significant tRNA. FEMS Microbiol Lett. 266:20-28.