Position: Associate Professor
School/Academic Group: School of Pharmacy, Wuhan University

Email: zhudongqing2005@hotmail.com

Education:

1998.09 - 2002.06  Shandong University，Bachelor

2002.09 - 2008.08 Shanghai Jiao Tong University，Ph.D.

Working Experience:

2008.09-2011.08  Georgia Institute of Technology, Postdoc

2011.09-now  Wuhan University, Associate Professor

Research Interests:

Molecular genetics, biochemistry of natural product biosynthesis, and combinatorial biosynthesis.

Publications:

1. Qiu J, Zhuo Y, Zhu D, Zhou X, Zhang L, Bai L, Deng Z. Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis. Appl Microbiol Biotechnol. 2011 Oct;92(2):337-45.

2. Zhu D*, Seo MJ*, Ikeda H, Cane DE. Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone.（*, co-first author） J Am Chem Soc. 2011 Feb 23;133(7):2128-31.

3. Seo MJ*, Zhu D*, Endo S, Ikeda H, Cane DE. Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone.（*, co-first author） Biochemistry. 2011 Mar 15;50(10):1739-54.

4. Zhao C, Coughlin JM, Ju J, Zhu D, Wendt-Pienkowski E, Zhou X, Wang Z, Shen B, Deng Z. Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender units. J Biol Chem. 2010 Jun 25;285(26):20097-108.

5. He Y, Zhu D, Bai L, Deng Z. Cloning of Antibiotic Biosynthetic Gene clusters from Genomic library by Narrow-down PCR. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY. 2009; 43(1):5-8. Chinese

6. Zhu D, He Y, Bai L, Deng Z. Positive Regulation of Avermectin Biosynthesis by AveR in Streptomyces avermitili. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY. 2008; 42(9):1448-1452. Chinese

7. Zhu D, He X, Zhou X, Deng Z. Expression of the melC operon in several Streptomyces strains is positively regulated by AdpA, an AraC family transcriptional regulator involved in morphological development in Streptomyces coelicolor. J Bacteriol. 2005 May;187(9):3180-7.

8. Zhang X, Zhu D, Wang D, Lin J, Qu Y, Yu S. [Study on xylose fermentation by Neurospora crassa].Wei Sheng Wu Xue Bao. 2003 Aug;43(4):466-72. Chinese.

9. Zhang X, Zhu D, Wang D, Lin J, Qu Y, Yu S. [Production and Some Properties of Xylanase from Neurospora crassa]. JOURNAL OF CELLULOSE SCIENCE AND TECHNOLOGY . 2002; 10(04). Chinese